作者: Jr-Kai Yu , Linda Z. Holland , Milan Jamrich , Ira L. Blitz , Nicholas D. Holland
DOI: 10.1046/J.1525-142X.2002.01057.X
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摘要: SUMMARY The full-length sequence and developmental expression of amphioxus AmphiFoxE4 are described. Transcripts the gene first detected in pharyngeal endoderm, where club-shaped gland is forming sub-sequently definitive itself. closely related to vertebrate genes encoding thyroid-specific transcription factor-2 (TTF2), which plays an early role morphogenesis thyroid a later hormone-mediated control function. In amphioxus, not specific because gland, only structure expressing gene, homologous thyroid; instead, homologue specialized region endoderm called endostyle. We propose that (a) pharynx amphioxus-like ancestor vertebrates included expressed FoxE4 as well endostyle did not, (b) soon disappeared line descent but (c) before there was homeogenetic transfer from nearby Such could have provided part genetic program enabling separate migrate away rudiment gland.