The emerging era of pharmacogenomics: current successes, future potential, and challenges

摘要: The vast range of genetic diversity contributes to a wonderful array human traits and characteristics. Unfortunately, consequence this is large variability in drug response between people, meaning that no single medication safe effective everyone. debilitating sometimes deadly consequences adverse reactions (ADRs) are major unmet problem modern medicine. Pharmacogenomics can uncover associations variation safety has the potential predict ADRs individual patients. Here we review pharmacogenomic successes leading changes clinical practice, as well areas probably be impacted by pharmacogenomics near future. We also discuss some challenges, solutions, remain for implementation testing into practice significant improvement safety.