Long-range heteronuclear coupling constants in 2,6-disubstituted purine derivatives.
作者： Eliška Procházková , Lucie Čechová , Petr Jansa , Martin Dračínský
DOI: 10.1002/MRC.3806
关键词:
摘要: Four- and five-bond heteronuclear J-couplings between the hydrogen H-8 carbons C-6 C-2 in a series of 7- 9-benzyl substituted purine derivaties with variuous substituents positions 2 6 were studied by coupled 13 C NMR H,C-HMBC experiments DFT calculations. We have found that for some derivatives, coupling H8-C2 is higher than four-bond H8-C6 coupling, which also evidenced stronger crosspeak HMBC. This finding contradicts generally accepted opinion only strong three-bond crosspeaks one weak can be observed HMBC spectra derivatives. The misinterpretation may lead to an incorrect determination derivatives' structure. Copyright © 2012 John Wiley & Sons, Ltd.
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