Prognostic differences in 8th edition TNM staging of esophagogastric adenocarcinoma after neoadjuvant treatment.
作者： Leila Sisic , Susanne Blank , Henrik Nienhüser , Sara Dorr , Georg Martin Haag
DOI: 10.1016/J.EJSO.2018.06.030
关键词:
摘要: Abstract Background Prognostic differences between pTN- and ypTN-categories the prognostic accuracy of 8th edition UICC-pTNM- AJCC-ypTNM-staging-system for esophageal gastric adenocarcinoma are unclear. Methods We retrospectively analyzed data 740 patients with esophagogastric adenocarcinoma, who underwent curative surgery (344 after neoadjuvant treatment [NT]) at our institution. Survival analyses were performed according to Kaplan-Meier (log-rank test). Multivariate using Cox proportional hazard model. Results Low ypT-categories did not discriminate overall survival (ypT0: reference; ypT1: HR1.0/p = 0.909; ypT2: HR0.9/p = 0.845; ypT3: HR1.5/p = 0.184; ypT4: HR2.8/p = 0.004) no difference was found ypN1- ypN2-disease (ypN0: HR0.4/p Conclusion value seems limited. After NT current UICC/AJCC-staging-system is able predict in but needs be reevaluated cancer modified if needed. A novel simplified staging system might more practicable NT.
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