Use of specific combinations of the triphala plant component extracts to potentiate the inhibition of gastrointestinal bacterial growth.

摘要: Abstract Ethnopharmacological relevance Triphala is used in Ayurveda to treat a wide variety of diseases, including numerous bacterial infections. Interestingly, the plant components triphala (Terminalia bellirica, Terminalia chebula and Emblica officinalis) are also good inhibitors growth when individually, yet preparations generally combination traditional medicine. Surprisingly, no previous studies have addressed reason why preferred over individual Aim study: To test compare antibacterial efficacy its component parts quantify their relative efficacies. The will be tested as combinations, thereby determining whether combining potentiates activity alone. Materials methods three were extracted using solvents varying polarity (methanol, water, ethyl acetate) aqueous resuspensions was quantified by disc diffusion broth microdilution MIC assays. Combinations extracts produced from against each species ΣFICs calculated determine class interaction. Where synergy detected, isobologram analysis optimal ratios. Artemia nauplii bioassay for toxicity GC-MS headspace profiling highlight terpenoid that may contribute triphala. Results methanolic triphala, T. E. officinalis displayed inhibitory all strains, with MICs often 250–750 μg/mL range. more potent than most components. Combining different resulted potentiation combinations compared Indeed, exception S. flexneri, potentiated at least one extracts, substantial proportion these displaying synergistic interactions. All found either non-toxic, or low moderate Conclusion Whilst inhibit multiple pathogenic bacteria, combinations. Therefore, usage materials not only extends profile mixture components, but it substantially towards partially explaining preference