Response surface analysis of chlortetracycline and tetracycline production with K-carrageenan immobilized Streptomyces aureofaciens
作者： M.L. Asanza Teruel , E. Gontier , C. Bienaime , J.E. Nava Saucedo , J.-N. Barbotin
DOI: 10.1016/S0141-0229(97)00045-8
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摘要: A full-factorial experimental design at three levels with two independent variables, carrageenan concentration (1.0, 1.5, and 2.0%) potassium chloride (0.3, 0.7, 1.1 M) was studied in order to analyze the effect of both factors on antibiotic production K-carrageenan-immobilized mycelia Streptomyces aureofaciens. The response surfaces obtained have indicated that concentrations a pronounced yield chlortetracycline (CTC) tetracycline (TC) produced by S. By exclusively varying immobilization condition, can be enhanced more than eight times (12.3 mg g−1 biomass for immobilized cells vs. 1.5 free cells) comparison free-cell mycelial cultures.
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