Sensory hair cell regeneration in the zebrafish lateral line.

摘要: Background: Damage or destruction of sensory hair cells in the inner ear leads to hearing balance deficits that can be debilitating, especially older adults. Unfortunately, damage is permanent, as regeneration epithelia does not occur mammals. Results: Zebrafish and other non-mammalian vertebrates have remarkable ability regenerate understanding molecular cellular basis for this regenerative will hopefully aid us designing therapies induce only possess but also lateral line system. Hair both organs are functionally analogous The a mechanosensory system found most aquatic detects water motion aids predator avoidance, prey capture, schooling, mating. Although cell occurs line, research date has focused on due its relatively simple structure accessibility. Conclusions: Here we review recent discoveries made during characterization zebrafish. Developmental Dynamics 243:1187–1202, 2014. © 2014 Wiley Periodicals, Inc.