Effects of rat fetuin on stimulation of bone resorption in the presence of parathyroid hormone.
作者： Osamu Nakamura , Jamil Ahsan Kazi , Tomokazu Ohnishi , Naokatu Arakaki , Qing SHAo
DOI: 10.1271/BBB.63.1383
关键词:
摘要: Rat fetuin, which is the rat counterpart of human α2-HS glycoprotein and bovine only detectable in calcified tissues such as bone matrices dentin, cells osteoblasts osteocytes immunohistochemically. The effect this protein on resorption was examined to study its physiological role metabolism. fetuin increased presence low concentrations parathyroid hormone (PTH), but it had no activity without PTH. increase by PTH plus inhibited addition chymostatin, an inhibitor for cathepsin L. Moreover, we found that when type I collagen from preincubated with digestion L increased. These findings suggest present matrix important resorption.
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