作者: Stephen C. Eyley
DOI: 10.1016/B978-0-08-052349-1.00045-7
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摘要: The Friedel–Crafts acylation reaction is one of the oldest reactions for preparation ketones by carbon–carbon bond formation, and major methods used aromatic ketones.1 However, an acid chloride in presence a Lewis also applicable to nonaromatic substrates. Whilst it has been known almost as long its better-known relative, aliphatic not often. Nevertheless, two reviews early acylations do summarize reaction’s history considerable body information.2,3