Irreversible ligands for nonsteroidal antiinflammatory drug and prostaglandin binding sites
作者： Leslie J. Askonas , Trevor M. Penning
DOI:
关键词:
摘要: Compounds such as 1-(4-bromoacetamidobenzyl)-5-methoxy-2-methylindole-3-acetic acid, N-(4-bromoacetamidophenyl) anthranilic acid and N-(3-bromoacetamidophenyl) function irreversible ligands for nonsteroidal antiinflammatory drug (NSAID) prostaglandin binding sites. It is therefore expected that these compounds, analogs thereof, will have utility anti-inflammatory drugs, affinity labeling agents use in chromatography.
lens.org 参考文章(37)
B. Yuan, C.L. Tai, H.H. Tai, 9-Hydroxyprostaglandin dehydrogenase from rat kidney. Purification to homogeneity and partial characterization. Journal of Biological Chemistry. ,vol. 255, pp. 7439- 7443 ,(1980) , 10.1016/S0021-9258(20)79722-X
G.J. Roth, C.J. Siok, Acetylation of the NH2-terminal serine of prostaglandin synthetase by aspirin. Journal of Biological Chemistry. ,vol. 253, pp. 3782- 3784 ,(1978) , 10.1016/S0021-9258(17)34756-7
S S Simons, J G Pumphrey, S Rudikoff, H J Eisen, Identification of cysteine 656 as the amino acid of hepatoma tissue culture cell glucocorticoid receptors that is covalently labeled by dexamethasone 21-mesylate Journal of Biological Chemistry. ,vol. 262, pp. 9676- 9680 ,(1987) , 10.1016/S0021-9258(18)47987-2
Horst-Juergen Krause, Process for the production of 2-benzyl fatty acids ,(1988)
Gerhard Baschang, Alfred Sallmann, Novel substituted phenylacetic acid amide compounds ,(1980)
M. J. H. Smith, Prostaglandins and aspirin: An alternative view Inflammation Research. ,vol. 5, pp. 315- 317 ,(1975) , 10.1007/BF02205237
William L. Smith, Flurbiprofen-sepharose chromatography of the prostaglandin synthetase from bovine seminal vesicles. Prostaglandins. ,vol. 10, pp. 983- 990 ,(1975) , 10.1016/S0090-6980(75)80045-1
Gerald J. Roth, Nancy Stanford, John W. Jacobs, Philip W. Majerus, Acetylation of prostaglandin synthetase by aspirin. Purification and properties of the acetylated protein from sheep vesicular gland Biochemistry. ,vol. 16, pp. 4244- 4248 ,(1977) , 10.1021/BI00638A018
Russell J. Taylor, Joseph J. Salata, Inhibition of prostaglandin synthetase by tolmetin (Tolectin, McN-2559), a new non-steroidal anti-inflammatory agent. Biochemical Pharmacology. ,vol. 25, pp. 2479- 2484 ,(1976) , 10.1016/0006-2952(76)90452-4
J. R. VANE, Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs Nature. ,vol. 231, pp. 232- 235 ,(1971) , 10.1038/NEWBIO231232A0