The viral and cellular forms of the Abelson (abl) oncogene.

摘要: The precision of molecular biology has allowed a better definition the components Abelson system. We know gene structures and products for cellular viral forms this family related tyrosine kinases. However, many basic issues first identified in early biological observations Abelson, Rabstein, others remain unanswered. precise pathway transformation biochemical terms remains unknown Ab-MLV all its relatives. Relatively little can be said to explain preferential growth stimulation certain hematopoietic cell types by other altered oncogene, no clear insights into function normal abl oncogene are available. Future progress will certainly depend on intensive efforts workers broader field control mechanisms.