Localized elevation of shear stress is related to coronary plaque rupture: a 3-dimensional intravascular ultrasound study with in-vivo color mapping of shear stress distribution.

摘要: Objectives The purpose of the present study was to assess relationship between shear stress distribution and coronary plaque rupture by means a new color-mapping program with 3-dimensional intravascular ultrasound (IVUS). Background Various in-vitro studies have demonstrated that vascular lumen is one important determinants vulnerability. However, in-vivo still unclear. Methods In study, IVUS used obtain spatial information on luminal geometry from 20 patients acute syndrome having distinct ulcerative lesion. These contours for each were first reconstructed into mesh polygons, then analyzed calculating fluid dynamics. flow considered be constant laminar one. Then, colorized mappings streamline, blood pressure, performed. original contour ruptured lesion obtained smoothing extrapolation. Results All had in proximal or top portion hill. color mapping, localized elevation pressure could observed surface. concentration frequently correlated site (kappa = 0.79). Conclusions Although absolute value not sufficient directly provoke mechanical destruction fibrous cap, high might trigger cap rupture.