Determination of blood flow and endothelial shear stress in human coronary artery in vivo.

摘要: This paper describes a system that permits, for the first time, in vivo determination of local velocity and endothelial shear stress major human coronary arteries. The purpose is to facilitate study plaque growth relationships between hemodynamic factors atherogenesis restenosis. three-dimensional anatomy segment right artery was determined immediately after directional atherectomy via combination intracoronary ultrasound biplane angiography. highly irregular geometry then represented curvilinear coordinates computational fluid dynamics technique used investigate detailed, intravascular profile distribution. We found minor flow reversals, significant swirling large variation stress, both axially circumferentially, within artery, even absence luminal obstruction. phenomena exhibit characteristics consistent with focal nature It concluded technology now exists determine variations fields vivo.