Recent trends in the diagnosis and management of biliary atresia in developing countries

摘要: Biliary atresia is a progressive obstructive cholangiopathy and fatal if left untreated within 2 years of life. Delay in referral because difficulties differentiating it from physiologic jaundice identifying an abnormal stool color. This paper presents overview on the diagnosis discusses current strategies management this disease developing countries. Articles were retrieved PubMed database using terms ‘biliary atresia’, ‘Kasai portoenterostomy’ ‘pediatric liver transplantation’. Contents article are also based personal experience authors. A national screening program color cards as part standard care neonatal period will greatly improve early detection biliary atresia. Outcomes diagnosed at earliest after birth, child referred to experienced pediatric hepatobiliary unit for evaluation, undergoes Kasai procedure. If portoenterostomy performed, nearly half all children survive into adolescence, about one-third likely have long-term, symptom-free life with normal biochemistry. Sequential treatment combining first line transplantation second results 90% survival