Sex differences in newborn myocardial metabolism and response to ischemia.

摘要: In children with congenital heart disease, female sex has been linked to greater in-hospital mortality associated low cardiac output, yet the reasons for this are unclear. Therefore, we examined whether newborn differences in heart's metabolic response ischemia exist. Left ventricular (LV) vivo and ischemic biopsies of male piglets were compared. Tissue ATP, creatine phosphate (CP), glycogen, anaerobic end-products lactate hydrogen ion (H+), key regulatory enzymes measured. Compared males, females displayed 14% lower 22% CP, 32% glycogen reserves (p < 0.05) at baseline. During ischemia, accumulated 17% 40% H+ accumulation 0.02), which was earlier cessation glycolysis ATP levels 0.02) compared males. Newborn demonstrated a ability use their reserves, resulting significantly 0.003) throughout period. Thus, disadvantage because they exhibited energy tissue lactic acidosis, both an increase susceptibility injury impair myocardial function on reperfusion.