Quantitative trait loci for variation in immune response to a Foot-and-Mouth Disease virus peptide

摘要: Infectious disease of livestock continues to be a cause substantial economic loss and has adverse welfare consequences in both the developing developed world. New solutions control are needed research focused on genetic loci determining variation immune-related traits potential deliver solutions. However, identifying selectable markers causal genes involved resistance vaccine response is not straightforward. The aims this study were locate regions bovine genome that immune post immunisation. 195 F2 backcross Holstein Charolais cattle immunised with 40-mer peptide derived from foot-and-mouth virus (FMDV). T cell antibody (IgG1 IgG2) responses measured at several time points All experimental animals (F0, F1 F2, n = 982) genotyped 165 microsatellite for scan. Considerable variability across was observed sire, dam age had significant effects specific points. There correlations within time, between IgG1 IgG2 traits, also some weak detected responses. whole scan 77 quantitative trait (QTL), 22 chromosomes, including clusters QTL BTA 4, 5, 6, 20, 23 25. Two reached 5% wide significance (on 6 24) one 20 1% significance. A proportion variance immunisation an FDMV component. Even though antigen relatively simple, humoral mediated clearly under complex control, majority located outside MHC locus. results suggest there may or impact primary secondary responses, whereas other specifically important early later phases response. Future fine mapping identified reveal variations underlying observed.