Alphafetoprotein as a Marker for Early Events and Carcinoma Development During Chemical Hepatocarcinogenesis

摘要: Animal bioassays for carcinogens depend on evaluation of morphologic changes in affected organs following carcinogen exposure. In rats and mice this procedure is expensive, the that occur before obvious cancer develops are subject to disagreement among pathologists. particular, reversible liver upon exposure chemical hepatocarcinogens have been given different interpretations by pathologists (1–5). Terms used vary from “preneoplastic,” implying a lesion will eventually develop into cancer, “hyperplastic” or “benign proliferative lesion,” which implies it does not cancer.