Evolution in Europe of African swine fever genotype II viruses from highly to moderately virulent.

摘要: Abstract Since its arrival in the Caucasus and Russia 2007, African swine fever virus (ASFV) has spread widely now affected EU countries of Estonia, Latvia, Lithuania, Poland and, more recently, Czech Republic Romania. The ever-increasing evidence seropositive wild boar certain areas suggests that some animals may be surviving for time or could even recovering from disease. This due to acquired immunity after primary infection and/or presence related viruses reduced virulence. To assess these hypotheses, two ASFV field strains Estonia were studied vivo groups domestic pigs. After an incubation period 4 ± 1.6 days, pigs inoculated intramuscularly with Es15/WB-Tartu 14 (group 2) developed clinical signs associated acute disease succumbed 7 11 days post (dpi). Pigs Es15/WB-Valga-14 1) had longer times (8 days) than those group 2 variable lesions compatible subacute chronic forms ASF; they at 25 dpi. in-contact both became infected 7–14 exposure exhibited manifestations pathological findings ranging Two per recovered completely protected against a subsequent homologous challenge-exposure performed 78 dpi. Under experimental conditions, no transmission occurred survivors susceptible sentinel housed together 137 infection.