LEUKEMIC TRANSFORMATION IN LYMPHOSARCOMA OF CHILDHOOD

摘要: Twenty-nine children with lymphosarcoma were admitted to The University of Texas M. D. Anderson Hospital and Tumor Institute from January 1, 1954, July 1960. Leukemia developed in 12, or 41%, these children. Boys who showed bone marrow transformation 2 years younger than boys remaining free leukemia; the girls no age differential was noted. Bone transition did not appear be related histologic type primary site involvement. median duration disease at time leukemic 27 weeks, range being 10 60 weeks. In eight had received radiation therapy, leukemia within a month following completion treatment. Another child found three months after receiving therapy. potential salvage effective prophylactic therapy makes this an important area for further investigation. One patients given 4-amino N10-methyl-pteroylglutamic acid (Methotrexate) has remained leukemia. number systemic adjuvant alkylating agents, corticosteroids actinomycin D failed prevent change. When compared "pure" leukemia, lymphosarcomatous origin responds poorly chemotherapy. most instances there is marked sensitivity corticosteroids, but may fleeting dependent on maintenance our series response mercaptopurine (Purinethol) Methotrexate could accurately determined, as steroids usually concurrently. phase 50% 23 emphasizing poor Sixty per cent died 44 weeks onset symptoms, irrespective whether not. Survival times during first longer whom developed. After survival achieved by those Two develop are living writing apparently disease; both 5-year survivors disease. A fatal outcome must currently expected when occurs. longest group been 137