Method of diagnosing on increased risk of alzheimer's disease

作者: Hilkka Soininen , Matej Oresic , Tuulia Hyotylainen

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摘要: This invention relates to a method for diagnosing subject's increased risk of progressing Alzheimer disease by measuring the concentration metabolite and comparing them respective mean healthy subjects. According Alzheimer's subject with mild cognitive impairment can be diagnosed without invasive technology.

参考文章(24)
T. Hänninen, M. Hallikainen, S. Tuomainen, M. Vanhanen, H. Soininen, Prevalence of mild cognitive impairment: a population-based study in elderly subjects Acta Neurologica Scandinavica. ,vol. 106, pp. 148- 154 ,(2002) , 10.1034/J.1600-0404.2002.01225.X
Peter Kampstra, Beanplot: A Boxplot Alternative for Visual Comparison of Distributions Journal of Statistical Software. ,vol. 28, pp. 1- 9 ,(2008) , 10.18637/JSS.V028.C01
M. P. Stoop, L. Coulier, T. Rosenling, S. Shi, A. M. Smolinska, L. Buydens, K. Ampt, C. Stingl, A. Dane, B. Muilwijk, R. L. Luitwieler, P. A. E. Sillevis Smitt, R. Q. Hintzen, R. Bischoff, S. S. Wijmenga, T. Hankemeier, A. J. van Gool, T. M. Luider, Quantitative Proteomics and Metabolomics Analysis of Normal Human Cerebrospinal Fluid Samples Molecular & Cellular Proteomics. ,vol. 9, pp. 2063- 2075 ,(2010) , 10.1074/MCP.M900877-MCP200
Sandra Castillo, Ismo Mattila, Jarkko Miettinen, Matej Orešič, Tuulia Hyötyläinen, Data analysis tool for comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry. Analytical Chemistry. ,vol. 83, pp. 3058- 3067 ,(2011) , 10.1021/AC103308X
David M. D. M. Holtzman, Xianlin Han, Diagnostic for early stage Alzheimer's disease ,(2002)
Howard Schulman, Sushmita Mimi Roy, Haihong Zhou, David Lowe, Christopher H. Becker, Compositions and methods relating to alzheimer’s disease ,(2006)
Heli Nygren, Tuulikki Seppänen-Laakso, Sandra Castillo, Tuulia Hyötyläinen, Matej Orešič, Liquid Chromatography-Mass Spectrometry (LC-MS)-Based Lipidomics for Studies of Body Fluids and Tissues Methods of Molecular Biology. ,vol. 708, pp. 247- 257 ,(2011) , 10.1007/978-1-61737-985-7_15
K Tsukamoto, K Kurokawa, T Matsushima, T Watanabe, T Teramoto, H Kato, Y Hashimoto, M Kinoshita, Determination by PCR-RFLP of apo E genotype in a Japanese population. Journal of Laboratory and Clinical Medicine. ,vol. 121, pp. 598- 602 ,(1993)
Rima F. Kaddurah-Daouk, K. Ranga Rama Krishnan, Rebecca Ann Baillie, Joseph P. McEvoy, Lipidomics approaches for central nervous system disorders ,(2006)