A Model of Evolutionary Selection: The Cardiovascular Protective Function of the Longevity Associated Variant of BPIFB4
作者： Francesco Villa , Albino Carrizzo , Anna Ferrario , Anna Maciag , Monica Cattaneo
DOI: 10.3390/IJMS19103229
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摘要: Evolutionary forces select genetic variants that allow adaptation to environmental stresses. The genomes of centenarian populations could recapitulate the evolutionary model and reveal secrets disease resistance shown by these individuals. Indeed, longevity phenotype is supposed have a background able survive or escape age-related diseases. Among these, cardiovascular diseases (CVDs) are most lethal their major risk factor aging associated frailty status. One example evolution revealed study centenarians genome four missense Single Nucleotide Polymorphisms (SNPs) haplotype in bactericidal/permeability-increasing fold-containing family B, member 4 (BPIFB4) locus enriched long living individuals: variant (LAV). LAV-BPIFB4 improve endothelial function revascularization through increase nitric oxide synthase (eNOS) dependent production. This review recapitulates beneficial effects its therapeutic potential for treatment CVDs.
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