Modulation of Visceral Nociception, Inflammation and Gastric Mucosal Injury by Cinnarizine

摘要: The effect of cinnarizine, a drug used for the treatment vertigo was assessed in animal models visceral nociception, inflammation and gastric mucosal injury. Cinnarizine (1.25–20 mg/kg, s.c.) caused dose-dependent inhibition abdominal constrictions evoked by i.p. injection acetic acid 38.7–99.4%. This cinnarizine (2.5 mg/kg) unaffected co-administration centrally acting dopamine D2 receptor antagonists, sulpiride, haloperidol or metoclopramide, peripherally antagonist domperidone, but increased agonist bromocryptine non-selective chlorpromazine. antinociception naloxone insenstive, enhanced propranolol, atropine yohimbine. antinociceptive prevented co-treatment with adenosine blocker theophylline ATP-sensitive potassium channel (KATP) glibenclamide. at 2.5 mg/kg reversed baclofen-induced antinociception. reduced immobility time Porsolt’s forced-swimming test 24%. inhibited paw oedema response to carrageenan lesions indomethacin rats. It is suggested that exerts anti-infl ammatory, protective properties. mechanism which modulates pain transmission likely involve receptors KATP channels.