The sensitivity of the pseudomurein-containing genus Methanobacterium to inhibitors of murein synthesis

摘要: The sensitivity to inhibitors of various steps murein synthesis was studied with six strains methanogenic bacteria. Four the belong genus Methanobacterium, which contains pseudomurein in its cell walls. This polymer-as well as murein-is not present two control organisms, Methanosarcina barkeri and Methanospirillum hungatii, were found be resistant all synthesis. four Methanobacterium antibiotics fosfomycin, D-cycloserine, vancomycin, penicillin G cephalosporin C, inhibit or function peptide subunits murein. On other hand, susceptible bacitracin, nisin, gardimycin enduracidin. It is therefore assumed that biosynthesis pseudomurein, respectively, may have some reactions so-called lipid cycle polymerization heteroglycan strands common.