Usefulness of urinary kidney injury molecule‐1 (Kim‐1) as a biomarker for cisplatin‐induced sub‐chronic kidney injury
作者： Ken-ichiro Nan-ya , Masatomo Kajihara , Natsuki Kojima , Masakuni Degawa
DOI: 10.1002/JAT.2999
关键词:
摘要: We explored biomarkers suitable for monitoring sub-chronic kidney injury using the three rat models of cisplatin (CDDP)-induced injury, which were designed to extend current knowledge beyond sub-acute exposure period. In pilot study, a single intravenous administration 1.5 mg kg(-1) CDDP rats was confirmed result in no histopathological changes. Subsequently, intravenously administered at dose 4 days 24-h intervals (Experimental model 1) and up 10 weeks weekly 2 3), changes blood urine components, such as recently recommended urinary (Kim-1, clusterin so on) traditional (blood urea nitrogen serum creatinine), examined together with renal tissues during development each model. these experimental models, significant increase Kim-1 observed prior tissues, retained after adverse Significant all other occurred along addition, treatment reduced time-dependent manner cessation drug. The present findings indicate that is most useful biomarker CDDP-induced among examined.
sci-hub.se 参考文章(44)
Daisuke Sasaki, Atsushi Yamada, Hitomi Umeno, Hiroshi Kurihara, Shunji Nakatsuji, Shiro Fujihira, Kenjiro Tsubota, Mihoko Ono, Akira Moriguchi, Kouji Watanabe, Jiro Seki, Comparison of the course of biomarker changes and kidney injury in a rat model of drug-induced acute kidney injury Biomarkers. ,vol. 16, pp. 553- 566 ,(2011) , 10.3109/1354750X.2011.613123
Estelle Marrer, Frank Dieterle, Impact of biomarker development on drug safety assessment. Toxicology and Applied Pharmacology. ,vol. 243, pp. 167- 179 ,(2010) , 10.1016/J.TAAP.2009.12.015
Mark E. Rosenberg, John Silkensen, Clusterin: physiologic and pathophysiologic considerations. The International Journal of Biochemistry & Cell Biology. ,vol. 27, pp. 633- 645 ,(1995) , 10.1016/1357-2725(95)00027-M
Frank Dieterle, Frank Sistare, Federico Goodsaid, Marisa Papaluca, Josef S Ozer, Craig P Webb, William Baer, Anthony Senagore, Matthew J Schipper, Jacky Vonderscher, Stefan Sultana, David L Gerhold, Jonathan A Phillips, Gérard Maurer, Kevin Carl, David Laurie, Ernie Harpur, Manisha Sonee, Daniela Ennulat, Dan Holder, Dina Andrews-Cleavenger, Yi-Zhong Gu, Karol L Thompson, Peter L Goering, Jean-Marc Vidal, Eric Abadie, Romaldas Maciulaitis, David Jacobson-Kram, Albert F Defelice, Elizabeth A Hausner, Melanie Blank, Aliza Thompson, Patricia Harlow, Douglas Throckmorton, Shen Xiao, Nancy Xu, William Taylor, Spiros Vamvakas, Bruno Flamion, Beatriz Silva Lima, Peter Kasper, Markku Pasanen, Krishna Prasad, Sean Troth, Denise Bounous, Denise Robinson-Gravatt, Graham Betton, Myrtle A Davis, Jackie Akunda, James Eric McDuffie, Laura Suter, Leslie Obert, Magalie Guffroy, Mark Pinches, Supriya Jayadev, Eric A Blomme, Sven A Beushausen, Valérie G Barlow, Nathaniel Collins, Jeff Waring, David Honor, Sandra Snook, Jinhe Lee, Phil Rossi, Elizabeth Walker, William Mattes, Renal biomarker qualification submission: a dialog between the FDA-EMEA and Predictive Safety Testing Consortium Nature Biotechnology. ,vol. 28, pp. 455- 462 ,(2010) , 10.1038/NBT.1625
Yuansheng Xie, Minoru Sakatsume, Shinichi Nishi, Ichiei Narita, Masaaki Arakawa, Fumitake Gejyo, Expression, roles, receptors, and regulation of osteopontin in the kidney. Kidney International. ,vol. 60, pp. 1645- 1657 ,(2001) , 10.1046/J.1523-1755.2001.00032.X
Joseph V Bonventre, Vishal S Vaidya, Robert Schmouder, Peter Feig, Frank Dieterle, Next-generation biomarkers for detecting kidney toxicity Nature Biotechnology. ,vol. 28, pp. 436- 440 ,(2010) , 10.1038/NBT0510-436
Michael A. Harding, Laurie J. Chadwick, Vincent H. Gattone, James P. Calvet, The SGP-2 gene is developmentally regulated in the mouse kidney and abnormally expressed in collecting duct cysts in polycystic kidney disease. Developmental Biology. ,vol. 146, pp. 483- 490 ,(1991) , 10.1016/0012-1606(91)90249-3
Frank Dieterle, Elias Perentes, André Cordier, Daniel R Roth, Pablo Verdes, Olivier Grenet, Serafino Pantano, Pierre Moulin, Daniel Wahl, Andreas Mahl, Peter End, Frank Staedtler, François Legay, Kevin Carl, David Laurie, Salah-Dine Chibout, Jacky Vonderscher, Gérard Maurer, Urinary clusterin, cystatin C, β2-microglobulin and total protein as markers to detect drug-induced kidney injury Nature Biotechnology. ,vol. 28, pp. 463- 469 ,(2010) , 10.1038/NBT.1622
Yutaka Tonomura, Noriko Tsuchiya, Mikinori Torii, Takeki Uehara, Evaluation of the usefulness of urinary biomarkers for nephrotoxicity in rats. Toxicology. ,vol. 273, pp. 53- 59 ,(2010) , 10.1016/J.TOX.2010.04.015
MM van Timmeren, MC van den Heuvel, V Bailly, SJL Bakker, H van Goor, CA Stegeman, Tubular kidney injury molecule-1 (KIM-1) in human renal disease The Journal of Pathology. ,vol. 212, pp. 209- 217 ,(2007) , 10.1002/PATH.2175