Measuring movement and location of the gastroesophageal junction: research and clinical implications

摘要: Understanding the physiology of gastroesophageal junction (GEJ) is important as failure its function associated with reflux disease, hiatus hernia, and cancer. In recent years, there have been impressive developments in high resolution technologies allowing measurement luminal pressure, pH, impedance. One obvious deficiency lack technique to monitor movement location GEJ over a prolonged period time. Proximal during peristalsis transient lower esophageal sphincter relaxations (TLESRs) due shortening longitudinal muscle esophagus. Techniques for measuring include fluoroscopic imaging mucosal clip, high-frequency intraluminal ultrasound, manometry, but these techniques limitations. Short segment recently found be more common than traditional may account prevalence intestinal metaplasia cancer seen at GEJ. While pHmetry available, no that can reliably continuously measure position squamocolumnar junction. A new reported precise continuous based on principle Hall effect. Reported studies validated accuracy both bench against gold standard, fluoroscopy. It has used alongside manometry studying behavior TLESRs swallows. are challenges this technique, promising ongoing developments. There exciting time ahead research clinical applications technique.