Inhibition of imiquimod-induced psoriasis-like dermatitis in mice by herbal extracts from some Indian medicinal plants

摘要: Psoriasis is a chronic autoimmune human skin disorder that characterized by excessive proliferation of keratinocytes, scaly plaques, severe inflammation and erythema. The pathophysiology psoriasis involves interplay between epidermal T lymphocytes, leukocytes vascular endothelium. Increased leukocyte recruitment elevated levels cytokines, growth factors genetic like interleukin (IL)-1β, IL-6, IL-17, IL-22, IL-23, tumour necrosis factor (TNF)-α, interferon (IFN)-γ, transforming (TGF)-β, toll-like receptor (TLR)-2, signal transducer activator transcription (STAT-3), 15-lipoxygenase (LOX)-2, coiled-coil alpha-helical rod protein 1 (CCHCR1), steroidogenic acute regulatory (StAR) vitamin D (VDR) are the most critical governing exacerbation psoriasis. In present study, an attempt was made to elucidate preventive role herbal extracts four dermo-protective Ayurvedic plants, Tinospora cordifolia (TC), Curcuma longa (CL), Celastrus paniculatus (CP) Aloe vera (AV), against psoriasis-like dermatitis. Parkes (P) strain mice were initially induced with dermatitis using topical application imiquimod (IMQ, 5 %), followed subsequent treatment examine their curative effect on dermatitis-induced mice. orally/topically administered according ED/LD50 doses. Phenotypical observations, histological examinations, semi-quantitative reverse PCR (RT-PCR) analyses blood samples control, IMQ-treated extract-treated lead conclusion combination extract from all plants instrumental in downregulating overexpressed which CL extract. Moreover, lesser yet positive response evident CP TC extracts. results suggest these can prove have tremendous potential disease open way new therapeutic strategies for treatment.