ASSOCIATION BETWEEN PSORIASIS SEVERITY AND TRANSFORMING GROWTH FACTOR β1 AND β2 IN PLASMA AND SCALES FROM PSORIATIC LESIONS
作者： Iwona Flisiak , Bożena Chodynicka , Piotr Porebski , Robert Flisiak
关键词:
摘要: Abstract Psoriasis is an inflammatory skin disorder with hyperproliferation of keratinocytes, that can be the result insufficient inhibitory effect transforming growth factors-β (TGF-β). The aim this study was to evaluate association between TGF-β1 and -β2 in plasma or scales from psoriatic lesions severity disease. TGF-β concentrations were measured enzyme immunoassay 41 patients psoriasis. mean TGF-β2 were: 15.7±1.4 0.15±0.02 ng/ml respectively. It also detectable varied 24 1159 0 2.95 pg/mg protein Plasma correlated significantly psoriasis area index (PASI). Significant correlation demonstrated concentration sedimentation rate disease duration. There no PASI TGF-β2, TGF-β2. highest mild form (203±65 pg/mg protein) lowest severe (147±54 pg/mg have been shown. These findings levels TGF-β1, should considered as a possible indicator activity.
elsevier.com
sci-hub.se 参考文章(22)
Donald P. Kadunce, Gerald G. Krueger, Pathogenesis of Psoriasis: Current Concepts Dermatologic Clinics. ,vol. 13, pp. 723- 737 ,(1995) , 10.1016/S0733-8635(18)30037-8
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
Masutaka Furue, Mitsuyasu Kato, Koichiro Nakamura, Kiyoko Nashiro, Kanako Kikuchi, Hitoshi Okochi, Kohei Miyazono, Kunihiko Tamaki, Dysregulated expression of transforming growth factor β and its type‐I and type‐II receptors in basal‐cell carcinoma International Journal of Cancer. ,vol. 71, pp. 505- 509 ,(1997) , 10.1002/(SICI)1097-0215(19970516)71:4<505::AID-IJC1>3.0.CO;2-Y
Cynthia J. M. Kane, Philip C. Hanawalt, A. Merrill Knapp, Jonathan N. Mansbridge, Transforming growth factor-beta 1 localization in normal and psoriatic epidermal keratinocytes in situ. Journal of Cellular Physiology. ,vol. 144, pp. 144- 150 ,(1990) , 10.1002/JCP.1041440119
T.J. Powell, H. Ben-Bassat, B.Y. Klein, H. Chen, N. Shenoy, J. Mccollough, B. Narog, A. Gazit, Z. Harzstark, M. Chaouat, R. Levitzki, C. Tang, J. Mcmahon, L. Shawver, A. Levitzki, Growth inhibition of psoriatic keratinocytes by quinazoline tyrosine kinase inhibitors. British Journal of Dermatology. ,vol. 141, pp. 802- 810 ,(1999) , 10.1046/J.1365-2133.1999.03152.X
Hironori Matsuura, Fumio Myokai, Jirô Arata, Sumihare Noji, Shigehiko Taniguchi, Expression of type II transforming growth factor-β receptor mRNA in human skin, as revealed by in situ hybridization Journal of Dermatological Science. ,vol. 8, pp. 25- 32 ,(1994) , 10.1016/0923-1811(94)90317-4
S. Kondo, Y. Hozumi, H. Maejima, K. Aso, Organ culture of psoriatic skin: effect of TGF-α and TGF-Β on epidermal structure in vitro Archives of Dermatological Research. ,vol. 284, pp. 150- 153 ,(1992) , 10.1007/BF00372708
James G Krueger, Jeffrey F Krane, D Martin Carter, Alice B Gottlieb, Role of Growth Factors, Cytokines, and Their Receptors in the Pathogenesis of Psoriasis Journal of Investigative Dermatology. ,vol. 94, pp. s135- s140 ,(1990) , 10.1111/1523-1747.EP12876121
Alicja Wiercińska-Drapało, Robert Flisiak, Danuta Prokopowicz, EFFECT OF ULCERATIVE COLITIS ACTIVITY ON PLASMA CONCENTRATION OF TRANSFORMING GROWTH FACTOR β1 Cytokine. ,vol. 14, pp. 343- 346 ,(2001) , 10.1006/CYTO.2001.0901
Alexander Kapp, The role of cytokines in the psoriatic inflammation Journal of Dermatological Science. ,vol. 5, pp. 133- 142 ,(1993) , 10.1016/0923-1811(93)90760-M