Recent advances in the discovery and delivery of vaccine adjuvants.

摘要: Adjuvant design has historically had a touch of alchemy at its heart due to reliance on the complex biology innate immune activation. However, new mechanistic understanding immunity, combined with adjuvant and delivery platforms for exploiting this knowledge, led significant advances recently. Although many challenges remain, field is moving rapidly proper tools methodologies are in place use traditional drug discovery engines guiding development vaccine adjuvants. In review, we outline current trends potentiator, system that will shape vaccines future.