Bi-stability of SUDR+K model of epidemics and test kits applied to COVID-19

作者: Andrea Gabrielli , Vinko Zlatić , Andrea Kadović , Irena Barjašić , Hrvoje Štefančić

DOI: 10.1007/S11071-020-05888-W

关键词:

摘要: Motivated with various responses of world governments to COVID-19, here we develop a toy model the dependence epidemics spreading on availability tests for disease. Our model, that call SUDR+K, is based usual SIR but it splits total fraction infected individuals into two components: those are undetected and detected through tests. Moreover, assume available increase at constant rate from beginning consumed detect individuals. Strikingly find bi-stable behavior between phase giant very small fraction. We show separation these regimes governed by match testing infection spread given time. also existence phases does not depend mathematical choice form term describing which tested detected. Presented research implies vigorous early activity, before enters its phase, can potentially keep under control, even change in or decrease size whole orders magnitude. For real application realistic ongoing epidemics, would gladly collaborate field epidemiologists order quantitative models process.

参考文章(10)
Martin Petric, Lorraine Comanor, Cathy A. Petti, Role of the laboratory in diagnosis of influenza during seasonal epidemics and potential pandemics. The Journal of Infectious Diseases. ,vol. 194, ,(2006) , 10.1086/507554
Pierre Nouvellet, Tini Garske, Harriet L. Mills, Gemma Nedjati-Gilani, Wes Hinsley, Isobel M. Blake, Maria D. Van Kerkhove, Anne Cori, Ilaria Dorigatti, Thibaut Jombart, Steven Riley, Christophe Fraser, Christl A. Donnelly, Neil M. Ferguson, The role of rapid diagnostics in managing Ebola epidemics Nature. ,vol. 528, pp. 109- 116 ,(2015) , 10.1038/NATURE16041
Shi Zhao, Qianyin Lin, Jinjun Ran, Salihu S. Musa, Guangpu Yang, Weiming Wang, Yijun Lou, Daozhou Gao, Lin Yang, Daihai He, Maggie H. Wang, Preliminary estimation of the basic reproduction number of novel coronavirus (2019-nCoV) in China, from 2019 to 2020: A data-driven analysis in the early phase of the outbreak. International Journal of Infectious Diseases. ,vol. 92, pp. 214- 217 ,(2020) , 10.1016/J.IJID.2020.01.050
Steven Sanche, Yen Ting Lin, Chonggang Xu, Ethan Romero-Severson, Nick Hengartner, Ruian Ke, The Novel Coronavirus, 2019-nCoV, is Highly Contagious and More Infectious Than Initially Estimated medRxiv. ,(2020) , 10.1101/2020.02.07.20021154
John EL Wong, Yee Sin Leo, Chorh Chuan Tan, None, COVID-19 in Singapore-Current Experience: Critical Global Issues That Require Attention and Action. JAMA. ,vol. 323, pp. 1243- 1244 ,(2020) , 10.1001/JAMA.2020.2467
Helena Legido-Quigley, Nima Asgari, Yik Ying Teo, Gabriel M Leung, Hitoshi Oshitani, Keiji Fukuda, Alex R Cook, Li Yang Hsu, Kenji Shibuya, David Heymann, Are high-performing health systems resilient against the COVID-19 epidemic? The Lancet. ,vol. 395, pp. 848- 850 ,(2020) , 10.1016/S0140-6736(20)30551-1
Ruiyun Li, Sen Pei, Bin Chen, Yimeng Song, Tao Zhang, Wan Yang, Jeffrey Shaman, Substantial undocumented infection facilitates the rapid dissemination of novel coronavirus (SARS-CoV-2) Science. ,vol. 368, pp. 489- 493 ,(2020) , 10.1126/SCIENCE.ABB3221
Dirk Brockmann, Dirk Brockmann, Benjamin F. Maier, Effective containment explains subexponential growth in recent confirmed COVID-19 cases in China. Science. ,vol. 368, pp. 742- 746 ,(2020) , 10.1126/SCIENCE.ABB4557
Paola Zola, Fabiana Zollo, Antonio Scala, Matteo Cinelli, Walter Quattrociocchi, Alessandro Galeazzi, Carlo Michele Valensise, Emanuele Brugnoli, Ana Lucia Schmidt, The COVID-19 social media infodemic Scientific Reports. ,vol. 10, pp. 16598- 16598 ,(2020) , 10.1038/S41598-020-73510-5