Evaluation of Nootropic Activity of Limonia acidissima Against Scopolamine-induced Amnesia in Rats.

摘要: Objectives The present study aimed to evaluate the nootropic activity of Limonia acidissima in rats. Materials and methods Methanolic extract was used activity, piracetam (200 mg/kg, i.p.) as a standard, scopolamine (1 induce amnesia. effect drugs on learning memory rats evaluated by using Y-maze task elevated plus maze scopolamine-induced amnesia models. Locomotor performed an actophotometer. Also, levels acetylcholinestrease, including histopathological examination rat brains, were assessed. Results showed increased alteration behavior response percentage spontaneous with task. In model, methanolic decrease transfer latency, which is indicative cognition improvement. locomotor decreased acetylcholinestrease enzyme significantly. A both low high doses effective regenerative scores compared normal control, negative control standard treatment. Conclusion results suggested that administration enhances different experimental revealed neuroprotective property extract. indicates may be treatment Alzheimer's disease.