TAP1 and TAP2 polymorphism in coeliac disease.
作者： StephenH. Powis , WilliamM.C. Rosenberg , Margaret Hall , Ian Mockridge , Susan Tonks
DOI: 10.1007/BF00210476
关键词:
摘要: Coeliac disease is strongly associated with HLA-DQ2, but it possible that additional major histocompatibility complex genes also confer susceptibility. Encoded close to HLA-DQ are two genes, TAP1 and TAP2, whose products believed transport antigenic peptides from the cytoplasm into endoplasmic reticulum. Comparison of 81 coeliac patients caucasoid controls revealed an increased frequency alleles TAP1A TAP2A in patient population. However, no significant difference was found when were compared HLA-DR -DQ matched controls, indicating linkage disequilibrium between TAP1A, TAP2A, HLA-DQ2. The TAP gene do not have a influence on susceptibility or resistance Northern European Caucasoid
springer.com
sci-hub.se 参考文章(29)
Chester A Alper, Ellen Fleischnick, Zuheir Awdeh, Aubrey J Katz, EJ Yunis, None, Extended major histocompatibility complex haplotypes in patients with gluten-sensitive enteropathy. Journal of Clinical Investigation. ,vol. 79, pp. 251- 256 ,(1987) , 10.1172/JCI112791
S. Bahram, D. Arnold, M. Bresnahan, J. L. Strominger, T. Spies, Two putative subunits of a peptide pump encoded in the human major histocompatibility complex class II region. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 88, pp. 10094- 10098 ,(1991) , 10.1073/PNAS.88.22.10094
P. M. van Endert, M. T. Lopez, S. D. Patel, J. J. Monaco, H. O. McDevitt, Genomic polymorphism, recombination, and linkage disequilibrium in human major histocompatibility complex-encoded antigen-processing genes. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 89, pp. 11594- 11597 ,(1992) , 10.1073/PNAS.89.23.11594
Mauro S. Malnati, Merce Marti, Timothy LaVaute, Dolores Jaraquemada, William Biddison, Robert DeMars, Eric O. Long, Processing pathways for presentation of cytosolic antigen to MHC class II-restricted T cells. Nature. ,vol. 357, pp. 702- 704 ,(1992) , 10.1038/357702A0
C. F. Higgins, S. C. Hyde, M. M. Mimmack, U. Gileadi, D. R. Gill, M. P. Gallagher, Binding protein-dependent transport systems. Journal of Bioenergetics and Biomembranes. ,vol. 22, pp. 571- 592 ,(1990) , 10.1007/BF00762962
Teodorica L. Bugawan, Giovanna Angelini, James Larrick, S. Auricchio, Giovanni B. Ferrara, Henry A. Erlich, A combination of a particular HLA-DPβ allele and an HLA-DQ heterodimer confers susceptibility to coeliac disease Nature. ,vol. 339, pp. 470- 473 ,(1989) , 10.1038/339470A0
M. Colonna, M. Bresnahan, S. Bahram, J. L. Strominger, T. Spies, Allelic variants of the human putative peptide transporter involved in antigen processing. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 89, pp. 3932- 3936 ,(1992) , 10.1073/PNAS.89.9.3932
Thomas Spies, Robert DeMars, Restored expression of major histocompatibility class I molecules by gene transfer of a putative peptide transporter. Nature. ,vol. 351, pp. 323- 324 ,(1991) , 10.1038/351323A0
Stephen H. Powis, Susan Tonks, Ian Mockridge, Adrian P. Kelly, Julia G. Bodmer, John Trowsdale, Alleles and haplotypes of the MHC-encoded ABC transporters TAP1 and TAP2 Immunogenetics. ,vol. 37, pp. 373- 380 ,(1993) , 10.1007/BF00216802
Roberto Tosi, Daniela Vismara, Nobuyuki Tanigaki, Giovanni Battista Ferrara, Filippo Cicimarra, Wilma Buffolano, Daniela Follo, Salvatore Auricchio, Evidence that celiac disease is primarily associated with a DC locus allelic specificity Clinical Immunology and Immunopathology. ,vol. 28, pp. 395- 404 ,(1983) , 10.1016/0090-1229(83)90106-X