Genetics of allergy and asthma

摘要: Learning Objectives This article summarizes the latest information regarding role of genetic influences in development allergic disorders and asthma reviews our current on some most likely genes responsible for these conditions. After reading this article, reader will have a better understanding molecular biologic techniques that are being used to understand complex such as allergies asthma. The should value how insight lead recognition presence specific subtypes require unique therapeutic interventions. can also be identify genetically at risk children thereby offer earlier intervention. Finally, causes next-hopefully curative-generation allergy therapeutics. Data Sources A detailed literature search was conducted. Studies considered relevant, well performed, appropriately controlled were used. Only human studies included only English language reviewed. Some presented is based author's own research experience. Study selection Material taken from peer-reviewed journals appropriate reviews. Results Conclusions Asthma diseases examples having an unmistakable predisposition, but absence classic Mendelian inheritance pattern. These "complex" caused by interactions multiple interacting protective contributing disease with each gene its variable tendency expressed. In addition, environmental triggers their expression. One approach identifying basis conditions perform genome-wide which location disease-causing chromosome identified nearby may subsequently identified. An alternative heritable components evaluate disordered structure or regulation within known involved disorders. Using approaches, suggested cytokine cluster 5 (including interleukins-3, -4, -5, -9, -13), 11 (the β chain high affinity IgE receptor), 16 IL-4 12 (stem cell factor, interferon-γ, insulin growth Stat 6 [IL-4 Stat]) contribute development. data support involvement antigen-presentation (MHC class II genes) T responses receptor α chain). disease-contributing alleles present β-adrenergic receptor, 5-lipoxygenase, leukotriene C4 synthase.