Mesenchymal stem cells: A new platform for targeting suicide genes in cancer.

摘要: One of the important strategies for treatment cancer is gene therapy which has potential to exclusively eradicate malignant cells, without any damage normal tissues. Gene-directed enzyme prodrug (GDEPT) a two-step approach, where suicide directed tumor cells. The encodes an that expressed intracellularly it able convert into cytotoxic metabolites. Various delivery systems have been developed achieve appropriate levels restricted expression chemotherapeutic drugs. Nowadays, mesenchymal stem cells (MSCs) drawing great attention as cellular vehicles systems. Inherent characteristics MSCs make them particularly attractive tools in cell therapy. They used largely their remarkable homing property toward sites and availability from many different adult tissues show anti-inflammatory actions some cases. do not stimulate proliferative responses lymphocytes, suggests low immunogenicity could avoid immune rejection. This review summarizes current state knowledge about genetically modified enable co-transduce variety therapeutic agents including genes (i.e., cytosine deaminase, thymidine kinase) order exert potent anti-carcinogenesis against various tumors growth. Moreover, we highlighted role exosomes released new platform targeting agents.