Pulmonary toxicity of chronic exposure to tobacco and biomass smoke in rats

摘要: OBJECTIVE: The objective of this study was to examine the separate and combined effects tobacco biomass smoke exposure on pulmonary histopathology in rats. INTRODUCTION: In addition smoking, indoor pollution developing countries contributes development respiratory diseases. METHODS: Twenty-eight adult rats were divided into four groups as follows: control group (Group I, no or smoke), exposed II), III), IV). After six months all sacrificed. Lung tissue samples examined under light microscopy. severity pathological changes scored. RESULTS: Group II differed from I histopathological alterations except intraparenchymal vascular thrombosis. There statistically significant difference between subjects exclusively II) those with observed IV found be more severe than III). DISCUSSION: Chronic caused an increase types lung injury. CONCLUSION: Exposure cigarette serious damage system, particularly concomitant smoke.