Acute and late complications after radiotherapy for prostate cancer: results of a multicenter randomized trial comparing 68 Gy to 78 Gy.

摘要: Purpose To compare acute and late gastrointestinal (GI) genitourinary (GU) side effects in prostate cancer patients randomized to receive 68 Gy or 78 Gy. Methods materials Between June 1997 February 2003, 669 were between radiotherapy with a dose of Gy, 2 per fraction using three-dimensional conformal radiotherapy. All T stages prostate-specific antigen (PSA) 120 days) was scored according the slightly adapted RTOG/European Organization for Research Treatment Cancer (EORTC) criteria. Results The median follow-up time 31 months. For toxicity no significant differences seen two randomization arms. GI Grade 3 reported as maximum 44% 5% patients, respectively. GU toxicity, these figures 41% 13%. No both arms except rectal bleeding requiring laser treatment transfusion ( p = 0.007) nocturia 0.05). 3-year cumulative risk RTOG/EORTC grade ≥2 23.2% 26.5% 0.3). risks 28.5% 30.2% respectively Factors related HT 0.01), pretreatment symptoms 0.04). prognostic factors were: 0.003), prior transurethral resection (TURP) 0.02). A history abdominal surgery 0.001) associated higher incidence whereas 0.006) ≥2. Conclusions Raising from resulted incidences but not significant, nocturia. Other than studied levels appeared be important predicting after radiotherapy, especially previous surgical interventions (abdominal TURP), hormonal therapy, presence symptoms.