Detection of mutation-specific epidermal growth factor receptor (E746-A750del) and lack of detection of human papillomavirus in oral squamous cell carcinoma
作者： M. Grimm , T. Iftner , H. Altaki , A. Iftner , J.P. Peters
DOI: 10.1016/J.IJOM.2014.04.006
关键词:
摘要: The clinical impact of epidermal growth factor receptor (EGFR) (E746-A750del) mutation and human papillomavirus (HPV) in oral squamous cell carcinoma (OSCC) is unclear. EGFR expression was analyzed OSCC specimens (n=161) by immunohistochemistry. results were correlated with characteristics on survival. Using INNO-LiPA Extra, high-risk HPV types genotyped 211 specimens. Positive (n=40/161, 25%) not associated any clinicopathological characteristics, prognostic factors, social habits (smoking, alcohol consumption), or tumour-specific HPV16 DNA detected three out samples (HPV16-positive: n=3/211, 1.4%). This study shows that mutation-specific do appear to be relevant the survival patients OSCC.
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sci-hub.se 参考文章(35)
Ya Wen Cheng, Gwo Tarng Sheu, Chih Yi Chen, Jan Ming Su, Jung Ta Chen, Ling Ling Hsieh, Hui Ling Chiou, Huei Lee, The Association of Human Papillomavirus 16/18 Infection with Lung Cancer among Nonsmoking Taiwanese Women Cancer Research. ,vol. 61, pp. 2799- 2803 ,(2001)
Miriam Reuschenbach, Katinka Kansy, Kira Garbe, Svetlana Vinokurova, Christa Flechtenmacher, Csaba Toth, Elena-Sophie Prigge, Oliver C. Thiele, Siegmar Reinert, Jürgen Hoffmann, Magnus von Knebel Doeberitz, Kolja Freier, Lack of evidence of human papillomavirus-induced squamous cell carcinomas of the oral cavity in southern Germany Oral Oncology. ,vol. 49, pp. 937- 942 ,(2013) , 10.1016/J.ORALONCOLOGY.2013.03.451
Klaus Laimer, Gilbert Spizzo, Guenther Gastl, Peter Obrist, Thomas Brunhuber, Dominic Fong, Verena Barbieri, Siegfried Jank, Wolfgang Doppler, Michael Rasse, Burghard Norer, High EGFR expression predicts poor prognosis in patients with squamous cell carcinoma of the oral cavity and oropharynx: a TMA-based immunohistochemical analysis. Oral Oncology. ,vol. 43, pp. 193- 198 ,(2007) , 10.1016/J.ORALONCOLOGY.2006.02.009
Mark W. Lingen, Weihong Xiao, Alessandra Schmitt, Bo Jiang, Robert Pickard, Paul Kreinbrink, Bayardo Perez-Ordonez, Richard C. Jordan, Maura L. Gillison, Low etiologic fraction for high-risk human papillomavirus in oral cavity squamous cell carcinomas Oral Oncology. ,vol. 49, pp. 1- 8 ,(2013) , 10.1016/J.ORALONCOLOGY.2012.07.002
Alexander Gröbe, Wolfgang Eichhorn, Meike Fraederich, Lan Kluwe, Yogesh Vashist, Johannes Wikner, Ralf Smeets, Ronald Simon, Guido Sauter, Max Heiland, Marco Blessmann, Immunohistochemical and FISH analysis of EGFR and its prognostic value in patients with oral squamous cell carcinoma. Journal of Oral Pathology & Medicine. ,vol. 43, pp. 205- 210 ,(2014) , 10.1111/JOP.12111
Jan Laco, Hana Vosmikova, Vendula Novakova, Petr Celakovsky, Helena Dolezalova, Lubos Tucek, Jana Nekvindova, Milan Vosmik, Eva Cermakova, Ales Ryska, The role of high-risk human papillomavirus infection in oral and oropharyngeal squamous cell carcinoma in non-smoking and non-drinking patients: a clinicopathological and molecular study of 46 cases Virchows Archiv. ,vol. 458, pp. 179- 187 ,(2011) , 10.1007/S00428-010-1037-Y
G. D. Plowman, G. S. Whitney, M. G. Neubauer, J. M. Green, V. L. McDonald, G. J. Todaro, M. Shoyab, Molecular cloning and expression of an additional epidermal growth factor receptor-related gene. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 87, pp. 4905- 4909 ,(1990) , 10.1073/PNAS.87.13.4905
Wei Wang, Sheng Han, Zhanpeng Yao, Xin Li, Ping Huang, Ming Zhang, Yan Chen, Jianjun He, A Study of Epidemiologic and Recurrence Factors of Oral Cancer Journal of Oral and Maxillofacial Surgery. ,vol. 70, pp. 2205- 2210 ,(2012) , 10.1016/J.JOMS.2011.09.040
Tatyana Isayeva, Yufeng Li, Daniel Maswahu, Margaret Brandwein-Gensler, Human Papillomavirus in Non-Oropharyngeal Head and Neck Cancers: A Systematic Literature Review Head and Neck Pathology. ,vol. 6, pp. 104- 120 ,(2012) , 10.1007/S12105-012-0368-1
Thomas J. Lynch, Daphne W. Bell, Raffaella Sordella, Sarada Gurubhagavatula, Ross A. Okimoto, Brian W. Brannigan, Patricia L. Harris, Sara M. Haserlat, Jeffrey G. Supko, Frank G. Haluska, David N. Louis, David C. Christiani, Jeff Settleman, Daniel A. Haber, Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib The New England Journal of Medicine. ,vol. 350, pp. 2129- 2139 ,(2004) , 10.1056/NEJMOA040938