Anti-influenza drugs: the development of sialidase inhibitors.

摘要: Viruses, particularly those that are harmful to humans, the 'silent terrorists' of twenty-first century. Well over four million humans die per annum as a result viral infections alone. The scourge influenza virus has plagued mankind throughout ages. fact new strains emerge on regular basis, out Asia, establishes continual socio-economic threat mankind. arrival highly pathogenic avian H5N1 heightened potential human pandemic point where many countries have put in place 'preparedness plans' defend against such an outcome. discovery first designer sialidase inhibitor and anti-influenza drug Relenza, subsequently Tamiflu, now inspired number continuing efforts towards next generation drugs. Such drugs may act 'first-line-of-defence' spread infection buy time for necessary vaccine development setting. Furthermore, can develop resistance therapeutics makes these extremely important. An overview role virus-associated glycoprotein (neuraminidase) some most recent developments based inhibition is provided this chapter.