Synthesis and evaluation of molecularly imprinted polymeric microspheres for highly selective extraction of an anti-AIDS drug emtricitabine
作者： Jia-ping Lai , Li Xie , Hui Sun , Fang Chen
DOI: 10.1007/S00216-013-6818-0
关键词:
摘要: The molecularly imprinted polymeric microspheres (MIPMs, 3∼5 μm), used as high-performance liquid chromatography (HPLC) and solid-phase extraction (SPE) packing materials for anti-AIDS drug emtricitabine (FTC), were synthesized by precipitation polymerization. effects of ratio chloroform to acetonitrile on the morphology diameter MIPMs investigated. prepared characterized HPLC. imprinting factor (2.26) suggests that resultant exhibit good recognition affinity FTC. In addition, in SPE material separation enrichment recovery FTC cartridge was 97.6 % standard solution. Finally, applied extract human serum samples. Impurities sample have been mostly removed, average 92.5 % obtained with a detection limit 0.005 μg/mL linear range 0.02∼4.0 μg/mL. method established can be monitor accuracy selectivity.
springer.com
sci-hub.se 参考文章(25)
Chao-meng Dai, Xue-fei Zhou, Ya-lei Zhang, Shu-guang Liu, Juan Zhang, Synthesis by precipitation polymerization of molecularly imprinted polymer for the selective extraction of diclofenac from water samples. Journal of Hazardous Materials. ,vol. 198, pp. 175- 181 ,(2011) , 10.1016/J.JHAZMAT.2011.10.027
Robert S. Jansen, Hilde Rosing, Wiete Kromdijk, Rob ter Heine, Jan HM Schellens, Jos H. Beijnen, Simultaneous quantification of emtricitabine and tenofovir nucleotides in peripheral blood mononuclear cells using weak anion-exchange liquid chromatography coupled with tandem mass spectrometry Journal of Chromatography B. ,vol. 878, pp. 621- 627 ,(2010) , 10.1016/J.JCHROMB.2010.01.002
Noel A. Gomes, Vikas V. Vaidya, Ashutosh Pudage, Santosh S. Joshi, Sagar A. Parekh, Liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for simultaneous determination of tenofovir and emtricitabine in human plasma and its application to a bioequivalence study. Journal of Pharmaceutical and Biomedical Analysis. ,vol. 48, pp. 918- 926 ,(2008) , 10.1016/J.JPBA.2008.07.022
Fengxia Qiao, Yuru Geng, Changqing He, Yupei Wu, Pengyu Pan, Molecularly imprinted microspheres as SPE sorbent for selective extraction of four Sudan dyes in catsup products Journal of Chromatography B. ,vol. 879, pp. 2891- 2896 ,(2011) , 10.1016/J.JCHROMB.2011.08.019
Jiaping Lai, Jun Wang, Zongwei Cai, Nucleoside reverse transcriptase inhibitors and their phosphorylated metabolites in human immunodeficiency virus-infected human matrices. Journal of Chromatography B. ,vol. 868, pp. 1- 12 ,(2008) , 10.1016/J.JCHROMB.2008.04.012
Murali Pendela, Dunge Ashenafi Mamade, Jos Hoogmartens, Ann Van Schepdael, Erwin Adams, Characterization of emtricitabine related substances by liquid chromatography coupled to an ion trap mass spectrometer Talanta. ,vol. 82, pp. 125- 128 ,(2010) , 10.1016/J.TALANTA.2010.04.004
S. Vo Duy, I. Lefebvre-Tournier, V. Pichon, F. Hugon-Chapuis, J.-Y. Puy, C. Périgaud, Molecularly imprinted polymer for analysis of zidovudine and stavudine in human serum by liquid chromatography-mass spectrometry. Journal of Chromatography B. ,vol. 877, pp. 1101- 1108 ,(2009) , 10.1016/J.JCHROMB.2009.02.068
Chunyan Wang, Alireza Javadi, Mehdi Ghaffari, Shaoqin Gong, A pH-sensitive molecularly imprinted nanospheres/hydrogel composite as a coating for implantable biosensors Biomaterials. ,vol. 31, pp. 4944- 4951 ,(2010) , 10.1016/J.BIOMATERIALS.2010.02.073
Serena Ambrosini, Sudhirkumar Shinde, Ersilia De Lorenzi, Borje Sellergren, Glucuronide directed molecularly imprinted solid-phase extraction: isolation of testosterone glucuronide from its parent drug in urine Analyst. ,vol. 137, pp. 249- 254 ,(2012) , 10.1039/C1AN15606C
Jia-Ping Lai, Reinhard Niessner, Dietmar Knopp, Benzo[a]pyrene imprinted polymers: synthesis, characterization and SPE application in water and coffee samples Analytica Chimica Acta. ,vol. 522, pp. 137- 144 ,(2004) , 10.1016/J.ACA.2004.07.003