Obesity, Metabolic Dysfunction, and Inflammation in Polycystic Ovary Syndrome

摘要: Obesity has grown in pandemic proportions with modern dietary habits and sedentary lifestyle as likely contributors. More recently, epigenetic phenomena have been implicated the development of obesity. Beyond its energy-storing capacity, adipose tissue acts an endocrine immunological organ. Accumulation excess adiposity causes dysfunction compartment. This ultimately leads to immune alterations characterized by inflammation, which then cause metabolic derangement imbalance. increases risk developing type 2 diabetes mellitus (DM), dyslipidemia, hypertension. In polycystic ovary syndrome (PCOS), presence obesity exacerbates signs symptoms disorder worsening preexisting chronic low-grade inflammation insulin resistance. many ways, pathophysiology PCOS runs parallel, except that proinflammatory effects promote are more pronounced compared what is observed alone. Nevertheless, diet-induced oxidative stress independent induce molecular may be underpinning resistance, atherogenesis, ovarian this disorder.