Expression of TAp73 and ΔNp73 isoform transcripts in thyroid tumours
作者： A. Ferru , S. Denis , J. Guilhot , H. Gibelin , J.M. Tourani
DOI: 10.1016/J.EJSO.2005.09.014
关键词:
摘要: Abstract Aim This study was aimed to determine p73 status in thyroid tumours. Methods Differential expression of the TAp73, ΔTAp73 transcripts measured a panel 60 malignancies by quantitative RT-PCR. Results By comparison normal tissue surrounding tumours, we observed significant downregulation TP73 adenomas and differentiated carcinomas. Correlations were found specimens between TAp73 ΔNp73 that p53, p14 ARF p16 INK4a , but these correlations lost carcinomas (PTC or FTC). Conclusions We have variations ΔNp73, expressions those different genes cancer.
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