Functional regulation of p73 and p63: development and cancer
作者： Gerry Melino , Xin Lu , Milena Gasco , Tim Crook , Richard A Knight
DOI: 10.1016/J.TIBS.2003.10.004
关键词:
摘要: The transcription factor and tumour suppressor p53 its two homologues p63 p73 form a family of proteins. show much greater molecular complexity than because they are expressed both as multiple alternatively spliced C-terminal isoforms, N-terminally deleted, dominant-negative proteins that reciprocal functional regulation. In addition, several other factors, such post-translational modifications specific common regulatory proteins, result overall in subtle modulation their biological effects. Although all p53, members regulators the cell cycle apoptosis, developmental abnormalities p73- p63-null mice do not enhanced susceptibility knockouts, suggesting complex processes modulate effects this
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Cliff Tabin, Arlene Sharpe, Daniel Caput, Christopher Crum, Frank McKeon, Annie Yang, Ronen Schweitzer, Deqin Sun, Mourad Kaghad, Nancy Walker, Roderick T. Bronson, p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development Nature. ,vol. 398, pp. 714- 718 ,(1999) , 10.1038/19539
Meredith Irwin, Maria Carmen Marin, Andrew C. Phillips, Ratnam S. Seelan, David I. Smith, Wanguo Liu, Elsa R. Flores, Kenneth Y. Tsai, Tyler Jacks, Karen H. Vousden, William G. Kaelin Jr, Role for the p53 homologue p73 in E2F-1-induced apoptosis Nature. ,vol. 407, pp. 645- 648 ,(2000) , 10.1038/35036614
Annie Yang, Nancy Walker, Roderick Bronson, Mourad Kaghad, Mariette Oosterwegel, Jacques Bonnin, Christine Vagner, Helene Bonnet, Pieter Dikkes, Arlene Sharpe, Frank McKeon, Daniel Caput, p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours Nature. ,vol. 404, pp. 99- 103 ,(2000) , 10.1038/35003607
Alea A. Mills, Binhai Zheng, Xiao-Jing Wang, Hannes Vogel, Dennis R. Roop, Allan Bradley, p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature. ,vol. 398, pp. 708- 713 ,(1999) , 10.1038/19531
Sergey Kovalev, Natalie D. Marchenko, Ute M. Moll, Alex I. Zaika, Overexpression of the wild type p73 gene in breast cancer tissues and cell lines. Cancer Research. ,vol. 59, pp. 3257- 3263 ,(1999)
B M Pützer, S Tuve, A Tannapfel, T Stiewe, Increased ΔN-p73 expression in tumors by upregulation of the E2F1-regulated, TA-promoter-derived ΔN′-p73 transcript Cell Death & Differentiation. ,vol. 10, pp. 612- 614 ,(2003) , 10.1038/SJ.CDD.4401205
Reuven Agami, Giovanni Blandino, Moshe Oren, Yosef Shaul, Interaction of c-Abl and p73α and their collaboration to induce apoptosis Nature. ,vol. 399, pp. 809- 813 ,(1999) , 10.1038/21697
Guojun Wu, Shuji Nomoto, Mohammad Obaidul Hoque, Tatiana Dracheva, Motonabu Osada, Chyi Chia Richard Lee, Seung Myung Dong, Zhongmin Guo, Nicole Benoit, Yoram Cohen, Peggy Rechthand, Joseph Califano, Chul-so Moon, Edward Ratovitski, Jin Jen, David Sidransky, Barry Trink, None, ΔNp63α and TAp63α regulate transcription of genes with distinct biological functions in cancer and development Cancer Research. ,vol. 63, pp. 2351- 2357 ,(2003)
Zhi-Min Yuan, Hisashi Shioya, Takatoshi Ishiko, Xiangao Sun, Jijie Gu, YinYin Huang, Hua Lu, Surender Kharbanda, Ralph Weichselbaum, Donald Kufe, None, p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage Nature. ,vol. 399, pp. 814- 817 ,(1999) , 10.1038/21704
Craig Stevens, Nicholas B La Thangue, E2F and cell cycle control: a double-edged sword. Archives of Biochemistry and Biophysics. ,vol. 412, pp. 157- 169 ,(2003) , 10.1016/S0003-9861(03)00054-7