Recollection-related increases in functional connectivity across the healthy adult lifespan

作者: Danielle R. King , Marianne de Chastelaine , Michael D. Rugg

DOI: 10.1016/J.NEUROBIOLAGING.2017.09.026

关键词:

摘要: In young adults, recollection-sensitive brain regions exhibit enhanced connectivity with a widely distributed set of other during successful versus unsuccessful recollection, and the magnitude change correlates individual differences in recollection accuracy. Here, we examined whether recollection-related changes their relationship performance varied across samples young, middle-aged, older adults. Psychophysiological interaction analyses identified increases both seed among throughout whole brain. The seed-based approach failed to identify age-related change. However, whole-brain analysis revealed number effects. Numerous pairs exhibited main effect age on change, mostly due decreased increasing age. After controlling for accuracy, however, these effects were most part no longer significant, those that detected now reflected A subset also an by interaction, driven weaker between accuracy We conjecture reflect neuromodulation.

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