Modulatory effects of snuff, retinoic acid, andß‐carotene on DMBA‐induced hamster cheek pouch carcinogenesis in relation to keratin expression
作者： PS Gijare , KV K. Rao , SV Bhide , None
DOI: 10.1080/01635589009514101
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摘要: Abstract The hamster cheek pouch (HCP) serves as an excellent model system not only for the studies on initiation and promotion but also modulation of experimental oral carcinogenesis. In our studies, HCPs treated with 7,12‐dimethylbenz[a]anthracene (DMBA) showed both stomach papillomas. Utilizing this system, we tested compared modulatory effects snuff, retinoic acid, s‐carotene incidence tumors keratin expression pattern. either alone or in combination DMBA, resulted snuff no tumors, those DMBA 10–15 % tumor incidence. Both acid a total inhibition DMBA‐induced carcinogenesis HCP well stomach. pattern alterations depending conditions.
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sci-hub.se 参考文章(30)
Abraham Rivenson, Joann DiBello, Dietrich Hoffmann, Joanne Braley, Stephen S. Hecht, John D. Adams, Induction of Oral Cavity Tumors in F344 Rats by Tobacco-specific Nitrosamines and Snuff Cancer Research. ,vol. 46, pp. 4162- 4166 ,(1986)
Werner W. Franke, Dorothea L. Schiller, Roland Moll, Stefanie Winter, Erika Schmid, Irmtraud Engelbrecht, Helmut Denk, Reinhard Krepler, Beatrix Platzer, Diversity of cytokeratins. Differentiation specific expression of cytokeratin polypeptides in epithelial cells and tissues. Journal of Molecular Biology. ,vol. 153, pp. 933- 959 ,(1981) , 10.1016/0022-2836(81)90460-5
Karen Gray Nelson, Thomas J. Slaga, Keratin modifications in epidermis, papillomas, and carcinomas during two-stage carcinogenesis in the SENCAR mouse. Cancer Research. ,vol. 42, pp. 4176- 4181 ,(1982)
Inhibition of Oral Carcinogenesis by a Protease Inhibitor Journal of the National Cancer Institute. ,vol. 76, pp. 447- 452 ,(1986) , 10.1093/JNCI/76.3.447
Allena Burge‐Bottenbley, Gerald Shklar, Retardation of experimental oral cancer development by retinyl acetate Nutrition and Cancer. ,vol. 5, pp. 121- 130 ,(1983) , 10.1080/01635588309513788
K. J. Ranadive, S. V. Gothoskar, A. R. Rao, B. U. Tezabwalla, R. Y. Ambaye, Experimental studies on betel nut and tobacco carcinogenicity. International Journal of Cancer. ,vol. 17, pp. 469- 476 ,(1976) , 10.1002/IJC.2910170409
M. Sporn, R. Squire, C. Brown, J. Smith, M. Wenk, S Springer, 13-cis-retinoic acid: inhibition of bladder carcinogenesis in the rat. Science. ,vol. 195, pp. 487- 489 ,(1977) , 10.1126/SCIENCE.835006
Ann Freedman, Gerald Shklar, Alcohol and hamster buccal pouch carcinogenesis. Oral Surgery, Oral Medicine, Oral Pathology. ,vol. 46, pp. 794- 805 ,(1978) , 10.1016/0030-4220(78)90311-0
Jan-Michael Hirsch, Guy Heyden, Holger Thilander, A clinical, histomorphological and histochemical study on snuff-induced lesions of varying severity. Journal of Oral Pathology & Medicine. ,vol. 11, pp. 387- 398 ,(1982) , 10.1111/J.1600-0714.1982.TB00180.X
Dennis B. Solt, Peter J. Polverini, Sayon Ray, Yanbiao Fei, Debajit K. Biswas, Early neoplastic commitment of hamster buccal pouch epithelium exposed biweekly to 7,12-dimethylbenz[ a ]anthracene Carcinogenesis. ,vol. 9, pp. 2173- 2177 ,(1988) , 10.1093/CARCIN/9.12.2173