Estrogen Receptors in the Rat Uterus STUDIES ON THE INTERACTION OF CYTOSOL AND NUCLEAR BINDING SITES
作者： G Shyamala , J Gorski
DOI: 10.1016/S0021-9258(18)91813-2
关键词:
摘要: Studies on the interrelationship of binding sites for estrogens found in cytosol and nuclear fractions rat uterus show that 17β-estradiol is first associated with a protein (9 S) present cytosol. The estrogen subsequently moves into nucleus where it bound to (5 which can be extracted from chromatin. Simultaneously movement nucleus, disappears or loses its ability bind estrogen. These other experiments are discussed terms hypothetical model binds receptor protein, bringing about change conformation subsequent nucleus.
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