Antagonism of cholera enterotoxin by anti-inflammatory agents in the rat.

摘要: THE treatment of cholera by intravenous fluids and electrolytes is well established and, if instituted before dehydration shock are irreversible, can completely protect the patient. But in times large-scale outbreaks neither personnel nor material (approximately 10–20 l. per patient) usually available1. Trials oral fluid electrolyte replacement therapy have been effective because absorption salts, water carbohydrates unimpaired such treatment2–4. This greatly simplifies treatment, but again limitation availability materials may not allow all victims during severe epidemics. Since both these methods do treat diarrhoea only attempt to replace losses throughout period (3–5 days) diarrhoea, patient still debilitated unable carry on normal activities. A drug which could be given orally reverse massive loss antagonizing effect enterotoxin secretory mechanisms small intestine has suggested as a rational means attack with least number trained people equipment5–7.