Combination of metformin with chemotherapeutic drugs via different molecular mechanisms

作者: Mei Peng , Kwame Oteng Darko , Ting Tao , Yanjun Huang , Qiongli Su

DOI: 10.1016/J.CTRV.2017.01.005

关键词:

摘要: Metformin, a widely prescribed drug for treating type II diabetes, is one of the most extensively recognized metabolic modulators which has shown an important anti-cancer property. However, fairly amount clinical trials on its single administration have not demonstrated convincing efficiency yet. Thus, recent studies tend to combine metformin with commonly used chemotherapeutic drugs decrease their toxicity and attenuate tumor resistance. These strategies displayed promising benefits. Interestingly, experiences diversity molecular mechanisms when it combines different drugs. For example, AMPK/mTOR signaling pathway activation plays major role hormone modulating In contrast, suppression HIF-1, p-gp MRP1 protein expression main mechanism anti-metabolites. Furthermore, combining antibiotics, inhibition oxidative stress inflammatory becomes novel pharmaceutical cardio-protective effect. Induction apoptotic mitochondria nucleus could be player synergistic effect combination cisplatin. down-regulation lipoprotein or cholesterol synthesis might undefined base taxane. deep exploration these critical understand help personalized administration. this mini-review, detailed combinations are discussed summarized. This work will promote better understanding provide precise targets identify specific patient groups achieve satisfactory treatment efficacy.

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