DNA damage response in patients with pediatric Acute Lymphoid Leukemia during induction therapy

摘要: Abstract Predicting the individual response to chemotherapy is a crucial challenge in cancer treatment. DNA damage caused by antitumor therapies evokes different repair mechanisms responses, such as Nucleotide Excision Repair (NER), whose components are being studied prognosis biomarkers and target therapies. However, few reports have addressed damages pediatric Acute Lymphoid Leukemia (ALL). Hence, we conducted an observational follow-up study with patients assess (by Comet Assay) gene expression from NER pathway during induction. Bone marrow samples diagnosis, 15th(D15) 35th (D35) days of treatment were collected 28 ALL. There was no increase index. there reduction cells low on D35 compared diagnosis. remained same, however, single patient, significant decrease observed, maybe due silencing or downregulation pathways. levels may influence clinical outcome, involved drug resistance risk relapse. In ALL, analyzed for first time behavior BM samples. Monitoring patient’s outcomes will help access implication our findings survival relapse rates.