Electroretinography in the Non-Human Primate as a Standardized Method in Toxicology

摘要: Electroretinogram traces including the five standard responses were recorded from 80 cynomolgus monkeys (Macaca fascicularis) under general anesthesia. First, after 30 minutes of dark adaptation, scotopic ERG was by seven measurements with increasing flash intensity rod threshold up to maximal response 2.6 cds/m2. A elicited flashes log units below flash. The oscillatory potentials then measured at 0.4 above At onset light adaptation and 10 thereafter, Hz flicker obtained in presence background illumination. For next photopic electroretinogram, three red cone intensity. final trace be single white Beyond requirements Standard for Clinical Electroretinography, electroretinograms also during course 4 minute intervals. results recordings performed accordance Electroretinography adapted electroretinogram correspond very well humans. Thus, monkey has proved an excellent animal model testing retinal (dys)functions toxicity assessment.