Ophthalmological Investigations in Toxicity Studies

摘要: Abstract Because of the high similarity morphology eye in humans and nonhuman primates (NHPs), NHP is a very good model to assess toxicity drugs eye. As standard for all laboratory practice (GLP) studies, posterior part (retina, optic nerve, macula, vessels) examined by direct and/or indirect ophthalmoscopy, anterior medium using slit lamp. More specific investigations are necessary provide more detailed information about potential influence compounds If identified as target organ, additional need be performed. Fundus photographs can taken document fundus findings progression these changes. Fluorescence angiography demonstrates vascular flow abnormalities trees within fundus. Electroretinography used detect functional defects photoreceptors, neuronal cells, glia cells. Intraocular pressure (IOP) measurements monitor drug-induced IOP Corneal thickness mainly determined studies with local administration cornea. In addition, specular microscopy able evaluate cornea endothelium. Scheimpflug photography technique further lens. Optical coherence tomography an imaging demonstrating tissue microstructure resolution approaching that light microscopy. This laser scanning ophthalmoscope investigate structure