The opiate antagonist naloxone does not arouse man from natural delta sleep.

摘要: To see if the opiate receptor/endorphin system plays a part in regulation of natural sleep humans effects antagonist naloxone on delta were examined. The behaviour each six healthy male volunteers aged 20–32 years was monitored by continuous recordings EEG, EOG, EMG, heart rate and respiratory for 3 nights. stages evaluated according to Rechtschaffen Kales. Naloxone (0.03 mg/kg body wt.) or saline as placebo administered intravenously double-blind randomized order during spontaneously occurring sleep, being observed recorded variables. never elicited arousal, either EEG subjects' behaviour. only effect noted an increase mean latency first REM stage. does not arouse from sleep. It seems unlikely therefore, that endorphins play role unless there are receptor subtypes involved which has low affinity man.